Endocrine Abstracts

Introduction: Glutathione system prevents oxidative stress development in erythrocites. When this system becomes depressed it predisposes a cell to apoptosis.Aim: To study glutathione system status in patients with diabetesMaterials and methods: Included patients were divided into four groups: group 1–41 almost healthy person (control group), group 2–41 patients with type 2 diabetes (T2D), group 3–40 patients with T2...

Introduction: Glutathione system prevents oxidative stress development in erythrocites. When this system becomes depressed it predisposes a cell to apoptosis.Aim: To study glutathione system status in patients with diabetesMaterials and methods: Included patients were divided into four groups: group 1–41 almost healthy person (control group), group 2–41 patients with type 2 diabetes (T2D), group 3–40 patients with T2...

Rationale: Obesity, prediabetes and diabetes are strongly associated with microcirculation (MC) abnormalities. It is known that pathological changes in microvessels predispose to CHD, CKD and retinopathy. Also it is widely recognized that biochemical and immunological changes accompanied with obesity and overweight lead to MC damage.ObjectiveOf the study was to assess changes in MC in patients with overweight and obesity.<p cla...

Background: Plasminogen activator inhibitor-1 (PAI-1) refers to group of is a serine protein inhibitors. It inhibits fibrinolysis and contributes to angiogenesis and atherogenesis processes. 4G/5G polymorphism was found to be associated with increased risk for cardiovascular diseases. It was of special interest to study PAI-1 polymorphism in patients with diabetes.Aim: Aim to study PAI-1 polymorphism in patients with type 2 diabetes (T2D) and concomitant...

Materials and methods: Included patients were divided into … groups: group 1 – 41 almost healthy person (control group), group 2 – 59 patients with prediabetes, group 3 – 41 patients with T2D, group 4 – 40 patients with T2D and CHD and group 5 – 88 patients with CHD. Activities of glutathione peroxidase (GP, mmol/min) and glutathione reductase (GR, mmol/min) and concentrations of reduced glutathione (GSH, mmol/l), oxidized glutathione (GSSG, mmol...

One of the key enzymes of antioxidant system is superoxide dismutase (SOD) that catalyses dismutation of superoxide anionic radical (O2−)l to molecular oxygen (O2) and hydrogen (H2O2). It was revealed that activity of SOD is decreased in patients with decompensated type 2 diabetes (T2D) but there is insufficient data about enzyme activity in compensated states and prediabetes.Purpose: To analys...

Background: One of the basic genetic factors that impact on development of diabetic nephropathy is enhanced expression of vascular endothelial growth factor (VEGF).Objective: To study association between VEGF polymorphism +405 G/C and early stage of chronic kidney disease (CKD) in patients with impaired glycemic states.Materials and methods: 73 included patients were divided into three groups: group 1–26 patients with prediabe...

To determine the relationship between indicators of inflammation and the blood redox status of type 2 diabetic (T2DM) patients with and without coronary heart disease (CHD).Forty four patients with T2DM and CHD (group 1), 67 patients with T2DM without cardiovascular complications (group 2), 89 healthy subjects (group 3) were included in this study. Serum concentrations of IL6 and IL8 were determined by ELISA using commercial kits. Concentrations of thiob...

Introduction: Many studies have found that markers of oxidative stress (OS) are significantly increased in diabetes mellitus, but only a limited number of studies describe the disturbance of OS in pre-diabetes.Objective: To study the state of the glutathione system in patients with disorders of carbohydrate metabolism and concomitant diseases of the cardiovascular system (CVS).Materials and methods: 181 patients were included under...